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Red Blood Cells

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Red Blood Cells(Erythrocycles) :

It carrying the oxygen carrying proteins haemoglobin that gives red color to blood.

Count :

4.5millions/ul in male
4.8millions/ul in female

Life span – 120days approxy

Shape :

Normal RBCs is a Biconcave disc shaped.

Size :

7 – 8 micrometer & and thickness 2 micrometer.

Life span :

120 days approxy.

• RBC serves important function such as Transport of maintenance of acid base balance.
• They do not have a nucleus. But they have a respiratory segment called Haemoglobin.
• They are synthesized in bone narrow found at the end of the long and short bones.

Erythrohypoesis :

• Process of which RBCs are formed. In the foetus RBC are formed in the liver speen and red bone narrow.
• After birth date they are formed only in the red bone narrow of sternum ribs vertebra etc.

Steps in the development of RBCs are as follows :

1. Proerythowblast
2. Erythrowblast
3. Reteurocycle (RBCs)
4. Erythrocycle

1. Proerythoblast :

It is the 1st stage. It is a smaller cell with degenerated nucleus. But haemoglobin is fully present.

Reticulocyte :

Develops from narmoblast. It contains haemoglobin and reticulum in cytoplasm.

Erythrocyte :

Which is fully developed RBC. It does not have a reticulum but contains adequate hemoglobin.

Both vita B12 & follic acid in necessary for the development of RBC s.

Pyrrole ring structure :

• 

Haemoglobin :

• It is the respiratory segment of Erythrocytes.
• The red color of blood is due to haemoglobin from RBC in the blood.
• It contains globin a protein which is conjugated with home. (Haemoglobin – heme + globin).
• Heme molecule contains 4 Pyrrote rings with irons in the center.
• The haemoglobin content of body is 15G/100ml of blood.
• Anemia occurs due to decrease in haemoglobin.

Functions :

• Transport of blood O2 & C2.
• Maintainance of acid base Equilibrium.
• As a source for a formation of bilirubin.

Haemolysis :

• It is the escape of haemoglobin from RBC in the blood.
• This is caused by hypotonic condition, certain drugs and toxin.

Thank you…