Red Blood Cells(Erythrocycles) :
It carrying the oxygen carrying proteins haemoglobin that gives red color to blood.
4.5millions/ul in male
4.8millions/ul in female
Life span – 120days approxy
Normal RBCs is a Biconcave disc shaped.
7 – 8 micrometer & and thickness 2 micrometer.
Life span :
120 days approxy.
- RBC serves important function such as Transport of maintenance of acid base balance.
- They do not have a nucleus. But they have a respiratory segment called Haemoglobin.
- They are synthesized in bone narrow found at the end of the long and short bones.
- Process of which RBCs are formed. In the foetus RBC are formed in the liver speen and red bone narrow.
- After birth date they are formed only in the red bone narrow of sternum ribs vertebra etc.
Steps in the development of RBCs are as follows :
- Reteurocycle (RBCs)
1. Proerythoblast :
It is the 1st stage. It is a smaller cell with degenerated nucleus. But haemoglobin is fully present.
Develops from narmoblast. It contains haemoglobin and reticulum in cytoplasm.
Which is fully developed RBC. It does not have a reticulum but contains adequate hemoglobin.
Both vita B12 & follic acid in necessary for the development of RBC s.
Pyrrole ring structure :
- It is the respiratory segment of Erythrocytes.
- The red color of blood is due to haemoglobin from RBC in the blood.
- It contains globin a protein which is conjugated with home. (Haemoglobin – heme + globin).
- Heme molecule contains 4 Pyrrote rings with irons in the center.
- The haemoglobin content of body is 15G/100ml of blood.
- Anemia occurs due to decrease in haemoglobin.
- Transport of blood O2 & C2.
- Maintainance of acid base Equilibrium.
- As a source for a formation of bilirubin.
- It is the escape of haemoglobin from RBC in the blood.
- This is caused by hypotonic condition, certain drugs and toxin.